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Over 2,500 Subjects Since 2005 Have Used Marijuana-Based Medicines In Controlled Clinical Trials

  • by Paul Armentano, NORML Deputy Director February 24, 2010

    [Editor’s note: This post is excerpted from this week’s forthcoming NORML weekly media advisory. To have NORML’s media advisories delivered straight to your in-box, sign up for NORML’s free e-zine here.]

    Researchers worldwide have performed 37 separate clinical trials assessing the therapeutic safety and efficacy of inhaled cannabis and marijuana-based medicines since 2005, according to a review published online last week in the journal Cannabinoids: The Journal of the International Association for Cannabinoid Medicines (IACM).

    Investigators from Leiden University in the Netherlands and the nova-Institut in Germany conducted a systematic review of recent clinical trial data pertaining to the medical use of whole smoked marijuana and cannabinoids.

    Authors identified 37 controlled studies since 2005 evaluating the therapeutic effects of cannabinoids. The trials involved a total of 2,563 subjects.

    Of the 37 clinical trials that have been recently conducted, eleven assessed the drug’s impact on chronic neuropathic pain – a difficult to treat type of pain resulting from nerve damage. Other studies assessed the efficacy of cannabinoids to treat multiple sclerosis-associated spasticity (nine separate studies); HIV/AIDS (four); experimental pain (four); intestinal dysfunction (two); nausea/vomiting/appetite (two); schizophrenia (two); glaucoma (one); and ‘other indications (two).

    Authors concluded, “Based on the clinical results, cannabinoids present an interesting therapeutic potential mainly as analgesics in chronic neuropathic pain, appetite stimulants in debilitating diseases (cancer and AIDS), as well as in the treatment of multiple sclerosis.”

    Last Wednesday investigators from the California Center for Medicinal Cannabis Research released the results of a series of double-blind, placebo-controlled trials that determined that cannabinoids could be “a first-line treatment” for patients suffering from neuropathy.

    Commenting on the review, NORML Deputy Director Paul Armentano said: “The safety and efficacy of marijuana as a medicine has now been established by the ‘gold standard’ of clinical study. Further, over 2,500 patients have used cannabinoids in controlled clinical trials over the past five years alone. This is a far greater total than the number of subjects that would likely be administered any other new drug pending United States FDA approval, and is a large enough population to once and for all establish marijuana’s objective value as a medicine.”

    43 Responses to “Over 2,500 Subjects Since 2005 Have Used Marijuana-Based Medicines In Controlled Clinical Trials”

    1. claygooding says:

      Meanwhile,the ONDCP is pushing marinol,again at their website,and surprise,surprise,they have issues with any recent studies done on marijuana. Of course it has nothing to do with the fact that the majority of their 15 billion dollar budget is justified and qualified with marijuana policy.
      Add that to the hole they have dug themselves into with their out and out lies to the American public for the last 35 years and figure out how many paper towels it will take to clean all that egg off their face.

    2. ChrisfromTN says:

      America’s leaders politicize crystal-ball issues, ignore facts, and substitute their own fear-based realities.

    3. somedood says:

      FDA blah blah
      bought and owned by Big Pharma!

      There is no God only Zuul.

    4. Joe "Ironman" Siler says:

      This, for me, is encouraging, and depressing at the same time. I am hoping to read a study done on cannabinoids ability to treat skin cancer. To date I have found none. I E-Mailed CMCR about this, and am awaiting a response. I personaly have used cannabis oil to treat Basal Cell Carcinoma, and have achieved notable success.

    5. The Oracle says:

      It is time to update the compilation of pro-cannabis science that was given to Congress. At least send each of them an addendum of the scientific evidence since last publication.

    6. sameoldwine says:

      I am proud to live at a time that the veil of misinformation is being lifted off this miracle drug. Rather ironic, huh?

      I just wish it had happened in the 70’s when the populace negan to wake up on the subject. Keith started getting the word out in what? ’72? Damn! Going on 30 years.

      You go NORML! Not much longer now…

    7. Brett says:

      and people STILL think this is the devils weed. gonna be at least another 5 years till we destroy this “drug war” mentality.

    8. Fort Worth, Tx says:

      everyone send this to your local newspaper and say you want more news on marijuana!!! peace

    9. Jed The head says:

      As more and more research is done we will all have better lives through cannabis. Better medicine, better food, and better textiles and better paper and cleaner energy. Oh yea will some one explain to me again why this plant has been prohibited.

    10. DB says:

      Great! …now what?

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