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Study: Non-Psychotropic Cannabinoid “Proven To Be Safe” In Humans

  • by Paul Armentano, NORML Deputy Director September 5, 2012

    The oral administration of the non-psychotropic cannabis plant constituent cannabidiol (CBD) is safe and well tolerated in humans, according to clinical trial data published online by the journal Current Pharmaceutical Design.

    Investigators at Kings College in London assessed the physiological and behavioral effects of CBD and THC versus placebo in 16 healthy volunteers in a randomized, double-blind, crossover trial.

    Investigators reported that the oral administration of 10 mg of THC was associated with various physiological and behavioral effects – such as increased heart rate and sedation – whereas the oral administration of 600 mg of CBD was not.

    They concluded, “There were no differences between CBD and placebo on any symptomatic, physiological variable. … In healthy volunteers, THC has marked acute behavioral and physiological effects, whereas CBD has proven to be safe and well tolerated.”

    A previous review of the use of CBD in human subjects, published in the scientific journal Current Drug Safety last year, similarly concluded that the compound was safe, non-toxic, and well tolerated.

    Separate investigations of CBD have documented the cannabinoid to possess a variety of therapeutic properties, including anti-inflammatory, anti-diabetic, anti-epileptic, anti-cancer, and bone-stimulating properties. In recent years, patients in states that allow for the use of cannabis therapy, particularly California, have expressed an interest in plant strains that contain uniquely high percentages of the compound.

    Cannabidiol, because it is an organic component of cannabis, is presently classified under federal law as a schedule I prohibited substance. Such substances are required by law to possess “a high potential for abuse,” “a lack of accepted safety … under medical supervision,” and “no currently accepted medical use in treatment in the United States.”

    Full text of the study, “Acute effects of a single, oral dose of d9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration in healthy volunteers” appears online in Current Pharmaceutical Design.

    47 Responses to “Study: Non-Psychotropic Cannabinoid “Proven To Be Safe” In Humans”

    1. Art Golden says:

      We need to abolish the DEA. Talk about government waste!

    2. Chris in WI says:

      Every cannabinoid is safe, you cannot die from toxicity when consuming cannabis. The shafer commision in the 70’s stated this! This shows how stupid most Americans are. Cannabis is illegal beause oil, lumber, and petrochemical companies didn’t want to compete with hemp.

      In 1935 the hemp decoritor was released in the US and then 2 years later bam it’s illegal. Then in feb of 1938 popular mechanics they published an article stating hemp was set to be the first $1billion crop. They didn’t realize it had been made illegal based on the testimony on a “scientist” who stated that after smoking cannabis he grew wings and flew around the world!?! It’s all public record… Look it up!

      If they repeated lies to get us here; it’s up to us to repeat the truth until we undo this!!!

    3. Ben says:

      Cannabis, (and related products), remains illegal due to several reasons:
      -1- voter mindsets based on media, not facts
      -2- beer, cigarette, pharmaceutical, law enforcement, and, at least previously,
      paper mills – all putting money into its negative reputation
      -3- specific legal departments in the US are afforded HUGE budgets for drug prohibition-
      and, being that marijuana is common
      it is low-hanging fruit, and so MUST remain
      Schedule I (to qualify for so much money)
      -4- additionally, many departments are able to
      keep/auction/resell/etc. many of the items
      that they acquire in this process

      In short:
      Marijuana has remained illegal because the
      voice of the people, has not collectively,
      spoken up about its ridiculous standing as
      an illegal drug, let alone Schedule I-
      and our media, and school systems decry it

      The government should only be able to educate,
      and, if found to be relaying false or, as happens, biased and unscientific ‘evidence’ to
      support its money collection efforts,
      should be held accountable.

      As it is, much scientific evidence has been accumulated, in spite of draconian laws and nonsensical efforts to keep it inaccessible.

      The minds of America’s voters,
      and those with ability to usefully voice their opinions, (via youtube, etc.),
      should rally to correct this tragedy of justice.

    4. bob manke says:

      my name is open to all comers. I am on policebook/facebook if you like. I am an Iowa marijuana advocate. I am joined with Carl Olsen’s law suit and have appeared with him in district court to force Iowa to correct problems at law over pot. It has been blabbered that federal law trumps state law. true. what is of great interest to pot warriors and freedom lovers is that federal regulatory law/codes do NOT trump state law. pot is made illegal by a federal regulatory code and not by federal law. federal congress has specifically stayed out of making pot illegal by federal law. WE CAN GET TO THEM WITH THIS PATHWAY! Watch Carl Olsen take on the dea Oct 15. and contact me any time on policebook/fb. I got more you’ll like. bob manke, afraid of the federalies no more.

    5. bob manke says:

      my name is open to all comers. I am on policebook/facebook if you like. I am an Iowa marijuana advocate. I am joined with Carl Olsen’s law suit and have appeared with him in district court to force Iowa to correct problems at law over pot. It has been blabbered that federal law trumps state law. true. what is of great interest to pot warriors and freedom lovers is that federal regulatory law/codes do NOT trump state law. pot is made illegal by a federal regulatory code and not by federal law. federal congress has specifically stayed out of making pot illegal by federal law. WE CAN GET TO THEM WITH THIS PATHWAY! Watch Carl Olsen take on the dea Oct 15. and contact me any time on policebook/fb. I got more you’ll like. bob manke, afraid of the federalies no more.

    6. Will Marcroft says:

      Michele Leonhart is a piece of shit for what she has done with the MMJ industry in the past few years. With all the evidence stacked up against the prohibition of Marijuana and the proven safety of it’s consumption, It’s just under negligence that her administration continues to treat the substance as if it was as destructive as Heroine and other more harmful substances.

    7. Reed says:

      @Will Marcroft,
      A petition should be started to force Leonhart (and the rest of the DEA, for that matter) to read and comprehend the research. Or something like that.

    8. Sandeezy says:

      Very true Ben (post above).
      As shown in this article, the medical benefits are real and it helps treat and sometimes helps prevent various illness’. In addition to hemp really competing with various industries, marijuana would take away business from all of these sickness’ it helps treat. These medical and pharmaceutical companies would lose business, and they really do not want to lose money. A majority of the population disagrees with its class 1 classification now and it is legal for medicinal use in many states, even the state all the lawmakers are, Washington D.C. It’s probably a matter of time until it is legalized. Medicine, tax revenue generated, hemp these are the three reasons it cannot be ignored.

    9. tokerman says:

      Well said on here. It is shameful how cannabis became outlawed and that alone should be reason enough for repeal of prohibition. In the name of jobs cannabis prohibition will continue. Previous blogger made an excellent point, that it’s only illegal through federal interstate regulatory laws but the is NO meaningful regulation being done at all! We must demand sensible regulation from the national departments charged to do it.

    10. Yeah seriously its ridiculous that even CBD’s are under trial people need this stuff to survive serious disease. Marijuana prohibition has to come to an end, it just does not make sense!

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