Study: Cannabinoid Could Potentially Cut Down On NSAID-Induced Hospitalizations

  • by Paul Armentano, NORML Deputy Director June 20, 2013

    NSAIDs (non-steroidal anti-inflammatory drugs such as ibuprofren) are among the most widely used analgesic substances in the world. However, the consumption of these products is associated with various adverse and life-threatening side-effects such as heart-attack, stroke, and internal bleeding. In fact, according to a 2001 analysis, in the United States alone, “gastrointestinal complications induced by nonsteroidal anti-inflammatory drugs (NSAIDs) cause more than 100,000 hospitalizations and an estimated 16,500 deaths annually.”

    Could these adverse gastrointestinal effects be offset by cannabis? A just published study in the European Journal of Pharmacology indicates that the most likely answer is ‘yes.’

    Researchers at West Virginia University assessed the impact of THC administration in an animal model of NSAID-induced gastric inflammation. Investigators reported that low doses of THC provided gastroprotective effects, significantly attenuating gastric hemorrhages and lesions.

    They concluded: “The results of the present study suggest that delta-9-THC … may also possess gastroprotective effects in NSAID using patients. … As current antacid regimens may be associated with undesirable effects, such as reduced bone density, increased risk of bacterial infection, and vitamin deficiencies, other approaches to prevent NSAID-induced gastric ulcers are needed. In addition to their gastroprotective effects, cannabinoids produce other beneficial effects, including pain reduction. … Thus, cannabinoids may have the added benefit of reducing the effective analgesic dose of NSAIDs, as well as reducing the incidence of NSAID-induced gastric ulcers.”

    Full text of the study, “Acute delta-9-tetrahydrocannabinol blocks gastric hemorrhages induced by the nonsteroidal anti-inflammatory drug diclofenac sodium in mice,” appears online in the European Journal of Pharmacology.

    11 Responses to “Study: Cannabinoid Could Potentially Cut Down On NSAID-Induced Hospitalizations”

    1. BAS Karen says:

      I have Rheumatoid Arthritis and just finished chemo and radiation for the Difuse Large B Cell Lymphoma I got due to the medication (Methotrexate) I was on for the RA. Now I hear about Raw Juicing Cannabis and can’t find where or if there are any test trials going on. Isn’t it our generation (I was born in 1951) now who’s sitting in our governmental seats? What the hell happened to them all? Cannabis has been used for thousands and thousands of years. It’s benefits are numerous and astounding. Not to mention that legalizing it could be a financial lucrative busines bringing in enough moneis to maybe get us out of this “recession”. Legal or otherwise . . . it’s going to be here long after those in the seats banning it are long dead. For their sakes, I hope they never have to experience pain and body degeneration and know that smoking or drinking the “devil weed” would have spared them pain and an early death.

    Leave a Reply