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Study: Non-Psychoactive Plant Cannabinoids Possess Synergistic Anti-Cancer Activity In Leukemia Cell Lines

  • by Paul Armentano, NORML Deputy Director October 15, 2013

    The concomitant administration of various non-psychoactive plant cannabinoids demonstrates synergistic anti-cancer activity in human leukemia cells, according to preclinical trial data published online this week in the journal Anticancer Research.

    Investigators from Saint George’s, University of London assessed the anti-cancer potential of three non-psychoactive cannabinoids (cannabidiol, cannabigerol, and cannabigevarin) and their respective acids on two types of leukaemia cell lines. Authors reported that the administration of cannabinoids in concert with one another resulted in “in additive/mildly synergistic interaction.”

    They concluded: “Our findings indicate that cannabinoids act with each other in a way such that doses for therapy could be reduced without a significant loss of activity. … [T]his study adds further support to the idea that cannabinoids can have a role in the cancer setting, not only as single agents, but also in combination with each other.”

    Commenting on the study in a press release, lead author Wai Lui said: “These agents are able to interfere with the development of cancerous cells, stopping them in their tracks and preventing them from growing. In some cases, by using specific dosage patterns, they can destroy cancer cells on their own. Used in combination with existing treatment, we could discover some highly effective strategies for tackling cancer. Significantly, these compounds are inexpensive to produce and making better use of their unique properties could result in much more cost effective anti-cancer drugs in future.”

    Plant cannabinoids as well as endogenous cannabinoids have been consistently shown to be potent anti-cancer inhibitors in preclinical models, halting the proliferation of glioma cancer cells, prostate cancer cells, breast carcinoma, lung carcinoma, and lymphoma, among other cancer cell lines. NORML’s review of much of this literature appears online here.

    An abstract of the study, “Enhancing the activity of cannabidiol and other cannabinoids in vitro through modifications to drug combinations and treatment schedules,” appears online here.

    26 Responses to “Study: Non-Psychoactive Plant Cannabinoids Possess Synergistic Anti-Cancer Activity In Leukemia Cell Lines”

    1. Demonhype says:

      This is getting so cool! Wouldn’t that be terrible, though, if we’ve essentially had an effective preventive, treatment and even cure for cancer and have been systematically destroying it! It’s like the plot to some Tales from the Crpyt episode. Seriously, I wonder how many DEA agents, Drug War cheerleaders, Drug War profiteers, and other such benighted people have had loved ones suffering and dying from cancer while actively fighting against the cure? I wonder how many of those agents burning and destroying MJ crops had loved ones with cancer who could have benefitted from their target?

      Note: I’m not saying it’s definitely a cure, but damn, it looks like that’s the direction it’s going. And even as a preventative and an effective treatment (esp. compared to chemo), that’s more than we’ve had in a long time.

      The DEA and various Drug War cheerleaders/profiteers will have even more crimes to answer for, even more innocent lives destroyed to answer for, even more innocent blood on their hands, once legalization becomes the law of the land. Man, I fantasize about trying them for crimes against humanity, though that justice will never happen I’m afraid.

      enddrugtesting.blogspot.com

    2. wbs 101 says:

      “these compounds are inexpensive to produce and making better use of their unique properties could result in much more cost effective anti-cancer drugs in future.”

      This is the part pharma doesn’t want people to know especially if it meant some people could treat cancer themselves. There is no way drug corporations could make a signifigant amount of money of this they will only lose money and a lot of money.

    3. dk says:

      What are they going to say, when it turns out that marijuana was the cure for cancer all along ? What will they say when it comes to light that they condemned millions upon millions to die and the cure was readily available ? Personally, I’ve been dealing with severe depression since I was a child and marijuana switches it off like a light and does it in less than a minute and now, it has become so expensive that I can no longer afford it. Damn the prohibitionists all to hell.

    4. TheOracle says:

      But the D.E.A. and most members of Congress know better because they are medical doctors, and have examined the totality of the medical evidence. NOT!

    5. bobwv says:

      So…burn 1-3 and take 1-2 tbs hemp seed oil a day?

    6. burny says:

      Eat medibles….cure cancer…….we have been trying to tell y’all that for a coons age.

    7. Stromboli says:

      Maybe someone could forward this to the US Supreme court!

    8. phrtao says:

      I wonder what aspects of this research will make it not credible for any consideration of re-scheduling cannabis ?
      (There is always something)

      [Paul Armentano responds: Because the findings are preclinical and have not been replicated in a large Phase III clinical trial.]

    9. Don Berry says:

      It’s been said before, but if these findings were about any other plant or substance, is there any question that it make headlines in all the major media and attract generous grants and other funding to expand research? Maybe it will happen this time…we’ll see.

    10. Elaine says:

      [Paul Armentano responds: Because the findings are preclinical and have not been replicated in a large Phase III clinical trial.]

      I’m pretty sure that the Feds, Big Pharma, and the DEA will do their best to make sure that these finds stay preclinical. The last thing they seem to want is proof of medical utility in any way shape or form. They seem to prefer generating lies and propaganda and locking up users in huge numbers…

      [Paul Armentano responds: Yes, there exists a Catch 22. The DEA demands P3 trials take place, but the illegality of cannabis largely prevents such trials from being conducted. Then the DEA points to the lack of such trials as a justification not to reschedule. In fact, this was the agency’s rational before the US Court of Appeals, which the Court upheld.]

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