Study: Oral Cannabis Extracts Associated With Seizure Control In Children With Treatment-Resistant EpilepsyApril 21, 2015
The administration of oral cannabis extracts is associated with the mitigation of seizures in adolescents with epilepsy, according to clinical data published this month in the journal Epilepsy & Behavior.
Researchers from the Colorado Children’s Hospital in Denver performed a retrospective chart review of 75 children provided cannabis extracts. Authors reported that 57 percent of subjects showed some level of improvement in seizure control while 33 percent reported a greater than 50 percent reduction in seizure frequency.
Researchers also reported “improved behavior/alertness” in one-third of subjects and improved motor skills in ten percent of treated patients. Adverse events were reported in 44 percent of subjects, 13 percent of which reported increased seizure activity. Overall, however, authors concluded that the extracts were “well tolerated by children.”
Separate clinical trial results publicized last week at the 67th Annual Meeting of the American Academy of Neurology reported that the administration of a proprietary form of CBD (cannabidiol) extracts decreased seizure frequency by 54 percent over a 12-week period in children with treatment-resistant epilepsy.
Survey data compiled by Stanford University in 2013 reported that the administration of cannabidiol-enriched cannabis decreased seizures in 16 of 19 patients with pediatric epilepsy.
Last February, the Epilepsy Foundation of America enacted a resolution in support of the “rights of patients and families living with seizures and epilepsy to access physician directed care, including medical marijuana.”
An abstract of the study, “Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy,” appears online here.
Our friends at High Times have launched a new campaign to call national attention to the next logical step in the country’s progression towards marijuana legalization: Freeing America’s Pot Prisoners
While the federal government has relaxed its stance on marijuana, allowing states to implement their own laws and no longer prosecuting businesses running in accordance with these laws, the status of those persecuted under old laws remains ignored. High Times’ petition calls for a rectification between the United States’ past marijuana laws and the current situation.
“President Obama recently commuted 20-odd prisoners serving life for a first time drug offense,” says CEO of Trans High Corporation and volunteer lawyer for “Lifers for Pot” Michael Kennedy. “Nineteen of them were convicted of coke and meth crimes… clearly much more serious misdeeds than pot dealing, but the big O only commuted one marijuana lifer. While we at High Times totally support these commutations, we have to press the President to look more closely at our Lifers For Pot and free them forthwith!”
The petition urges Attorney General Holder, as well as the Attorney General Designate, to recommend for the immediate release of all non-violent marijuana offenders and to provide new sentencing guidelines to give law enforcement other options besides imprisoning non-violent offenders. In 2013, 693,482 people were arrested for a marijuana law violation and of those, 609,423 (88 percent) were charged only with possession.
Even in California, where marijuana prisoners are beginning to be released, 482 non-violent marijuana offenders remain in prison, which is not only a high human cost but a huge cost to taxpayers. For this reason, High Times is soliciting Attorney General Kamala Harris to act as an example for the other 49 states by immediately releasing these prisoners and recommending alternatives to incarceration for the use, sale, and cultivation of marijuana.
Some non-violent marijuana prisoners, such as Antonio Bascaró and Jeff Mizanskey, have been imprisoned for non-violent offenses for much of their lives. Both fear perishing in prison without seeing a country swept with marijuana reform. High Times hopes this petition can change the fates of these two men and the others still imprisoned for non-violent marijuana crimes.
Recreational marijuana is now legal in four states and the District of Columbia, medical use is legal in 24 others and 58 percent of Americans are in favor of legalized, regulated marijuana. This change in American perspective on marijuana, High Times argues, is the exact reason why non-violent offenders should be released.
High Times’ petition is found at http://bit.ly/420Freedom.
Signers are asked to spread word of the petition using #FreePotPrisoners across social media.
As Joe Cocker famously pleaded in 1969 at Woodstock, "Let’s go get stoned."
Happy 4/20 to marijuana smokers throughout the land. Today is our annual holiday, an occasion to celebrate all things related to marijuana and marijuana smoking.
I am delighted to be spending my day at the High Times Denver Cannabis Cup, the largest of all the cannabis celebrations each April 20th, where NORML has a booth each year, and where we have the opportunity to meet and greet thousands of other marijuana aficionados. If you are in Denver, please do stop by our booth today and introduce yourself.
Legalizing marijuana is serious business, and it requires the cumulative, ongoing effort of thousands of hard-working, committed citizen-activists to end prohibition and change state and federal policies that have been in place for more than 75 years. More than 700,000 Americans continue to be arrested each year on marijuana charges, needlessly damaging the lives and careers of these otherwise law-abiding citizens who prefer to smoke marijuana when they relax in the evening, just as millions of other Americans enjoy a beer or a glass of wine when they relax. And certainly the need to stop arresting responsible marijuana smokers must remain our top priority.
Today marks the 20th anniversary of NORML publicly celebrating the now international ‘cannabis consumers day of celebration‘ known as ‘420.’
With a remarkable degree of cultural and media penetration April 20 is now a well recognized day in America for celebration and/or protest regarding cannabis laws; in states where cannabis has been legalized (Alaska, Colorado, Oregon and Washington State) this day marks an opportunity to celebrate hard fought victories. In the other forty-six states that unfortunately have not yet shifted from cannabis prohibition to tax-and-regulate, NORML members and supporters will be protesting or engaging in community service activities to bring attention to the need for marijuana law reform.
NORML Advisory Board member Bill Maher had some fun with Monday’s festivities by calling for April 20 to become a national holiday via a change.org petition online, as well as to poke some good fun at fellow Advisory board members Willie Nelson and Woody Harrelson.
NORML’s chapter network serves as national hub for 420-related activities across the country. Also, this Monday, NORML and our chapters will be converting our respective webpages to reflect the #GoGreen2015 social media campaign.
Also, one of the more significant fundraising projects for NORML occurs today when the organization makes available a collector’s item t-shirt reflecting this unique celebration, on this unique day, at this specific time at the end of cannabis prohibition (i.e., this year’s design highlights the four states that have thus far legalized cannabis). This year’s shirt design is also available in a hemp and cotton blend too.
With as many as half a dozen or more states expected to pass legalization initiatives in 2016, and survey after survey showing an increasing majority of Americans favoring legalization, this is by any measure the most exciting time ever in cannabis law reform!
When NORML was founded in 1970 about 10% of the population supported cannabis legalization, today most polls indicate 55% plus.
Please make a charitable donation to NORML on this April 20th to help the organization keep the momentum rushing forward towards legalization, and away from nearly eighty years of a failed cannabis prohibition policy–and receive a one-of-a-kind NORML ‘420’ t-shirt for 2015.
Thanks for supporting NORML’s longstanding public advocacy for cannabis law reform, have a safe and fun 4/20!!
Four down, forty-six more to go…
-Allen St. Pierre
While we now enjoy the support of a majority of the American public to end marijuana prohibition, 64 percent of those same people nonetheless still have an overall negative impression of marijuana smokers. All to often they see us as slackers who fail to live up to our full potential, and whose primary interest in life is getting stoned.
While much of that disconnect is likely the result of decades of “reefer madness” propaganda, some of it also results from careless conduct on the part of some marijuana smokers that reinforces those negative stereotypes. We can’t change the past, but we do have the ability to demonstrate by our conduct that marijuana smokers also have full, rich lives filled with family and friends, and influenced by our intellectual and professional pursuits. We are about more than just getting high.
In fact, those of us who smoke marijuana are otherwise indistinguishable from other Americans. We come in all shapes and sizes, with a full range of political beliefs and lifestyles and professional goals. For the vast majority of smokers, our use of marijuana does not define our lives; it is but one factor, including family, work, education, sports, literature, music and faith, that taken together, define who we are as individuals.
Of course, those of us who smoke enjoy the benefits of marijuana, from its relaxing qualities to its ability to allow one to become more creative, and expansive, in our thinking. I do believe that marijuana smoking plays a very positive role in my life and in my work, and I am sure many other smokers feel the same.
Everyone needs some private time, and getting “high” — like sex — is not a dirty word. There are times when we can lay aside our responsibility for a time, and enjoy the freedom of just getting high with friends. But that does not suggest that marijuana smoking should become the center of one’s life, or that one should be stoned all waking hours. Most jobs and educational pursuits require a clear mind and a steady focus that are not possible if one is experiencing the short-term memory loss that is an integral part of the marijuana “high.”
And a healthy family life requires shared experiences and interactions that depend on a degree of personal communication that is frequently interrupted if one of the parties is stoned. And, frankly, like most other activities in life, getting “high” is more pleasurable when experienced in moderation.
Principles of Responsible Marijuana Use
Here are a few common sense suggestions for enjoying marijuana in a responsible manner, which will, over time, help persuade the non-smokers that those of us who do smoke are nonetheless good, productive citizens. Many of these are based on The Principles of Responsible Cannabis Use, adopted by the NORML board of directors back in 1996, and found on the NORML website.
1. Be sensitive to the set and setting before lighting-up. A responsible marijuana consumer should be vigilant to the conditions – time, place, mood, etc. – and should not hesitate to say “no” when those conditions are not conductive to a safe, pleasant and/or productive experience. And we must always respect the rights of others.
The responsible marijuana smoker does not violate the rights of others, observes accepted standards of courtesy and public propriety, and respects the preferences of those who wish to avoid marijuana entirely. Regardless of the legal status of marijuana, responsible users should adhere to emerging tobacco smoking protocols in public and private places. It is important politically that non-smokers do not feel as if those of us who smoke are forcing our personal preferences on them.
2. No driving while impaired with marijuana. A responsible marijuana consumer should not operate a motor vehicle or use other dangerous machinery while impaired by marijuana or other substances (including alcohol and some prescription medications).
Public safety requires that impaired drivers be kept off the roads, and that objective measures of impairment be developed to detect marijuana impairment; not simply testing for the presence of THC.
3. Resist abuse. Most marijuana use is essentially harmless; some is not. The use of marijuana, to the extent it impairs health, personal development or achievement, is abuse and should be resisted.
For example, the concept of “wake and bake” needs to disappear from our lexicon. It is a variation on the “stupid stoner” stereotype of a smoker who sits home on his couch all day and stays stoned from morning until night. That image feeds the prejudice that exists among non-smokers towards those of us who smoke.
“Wake and bake” might work on an occasional camping trip, or a day spent walking in the woods, but it should not be a regular part of one’s life.
4. Be careful with edibles and concentrates. When consumed as an edible, the THC in marijuana requires up to 90-minutes, or even longer, to take effect, and it is therefore difficult to titrate the dosage. 10 milligrams is generally considered a single dose for an experienced user, and perhaps 5 milligrams for a novice user.
One who consumers too much of an edible will likely have a frightening, unpleasant experience, similar to a bad acid trip, which sometimes ends up in an emergency room. Those incidents are not life threatening or fatal, but they do reinforce negative views of marijuana smoking by non-smokers, and complicate our task of moving legalizing forward.
And the same warning applies to concentrates. Novice users especially need to go slowly when using concentrates, to avoid an unpleasant overdose; and even experienced smokers frequently are surprised by the strength of concentrates. Just as alcohol drinkers learn to use far less if they are drinking hard liquor than if they are drinking beer, those who use edibles and concentrates must acknowledge the distinction from regular marijuana and adjust their intake.
5. Moderation in all things. Just as alcohol drinkers learn that moderation is necessary to insure a pleasant experience, and to avoid an unpleasant one, so too with marijuana smoking. Getting as high as possible should not be the goal. The purpose of marijuana smoking should be to reach a nice, comfortable, pleasant high that permits enjoyable social interaction with others, and enhances the experience of activities such as eating, listening to music, walking in the woods, having sex, etc.
In fact, sometimes marijuana smokers prefer a mild level of intoxication, which has resulted in the arrival of many low-THC strains and edibles in states in which it is legal.
If those of us who smoke marijuana can generally follow these basic guidelines, we will begin to overcome the negative impression of recreational marijuana smokers that persist among nearly two out of three non-smokers, which in turn will permit us to make the remaining cultural and legal changes required to end unfair discrimination against responsible marijuana smokers.