Sanofi-Aventis S.A.’s (SNY) anti-obesity pill Acomplia has been linked to five deaths and 720 adverse reaction since its U.K. launch in 2006, according to a document posted on the U.K. drug regulator’s website Tuesday.
One of the deaths was due to suicide, said the Medicines and Healthcare products Regulatory Agency, or MHRA, document, which recorded adverse side effects up until May 9.
The drug, a new kind of obesity treatment that blocks certain brain receptors that regulate appetite, last year was rejected by a panel of U.S. Food and Drug Administration experts on concerns that the drug increases the number of psychiatric events like depression and suicidal thinking among users.
… Despite withdrawing its application to market the drug in the U.S., where it was to have been known as Zimulti, Sanofi-Aventis has plans to resubmit it to the FDA and other regulators in 2009 for approval as a treatment for type 2 diabetes.
In a study released in 2006, Acomplia showed promise as a diabetes treatment after patients who took the pill for a year reported improvements in blood sugar control and cholesterol along with modest weight loss.
However, a recent study of the drug in obese heart patients found more than 40% of those who took the drug developed psychiatric problems, while another study, published last month, raised concerns about using drugs like Acomplia in children.
Brain scans showed the hippocampus and amygdala were smaller in men who were heavy marijuana users compared to nonusers. … The men had smoked at least five marijuana cigarettes daily for on average 20 years.
The answer: If they didn’t, there wouldn’t be any purported risks left to write about.
I mean, seriously, imagine if these scientists had tried recruiting 15 subjects who drank at least five shots of vodka every day for 20 years? That is, if they could find 15 subjects who were still alive.
Heavy marijuana use can boost blood levels of a particular protein, perhaps raising a person’s risk of a heart attack or stroke, U.S. government researchers said on Tuesday. …The marijuana users in the study averaged smoking 78 to 350 marijuana cigarettes per week.
The study did not look at whether the heavy marijuana users actually had heart disease.
So here we go again. Three-hundred and fifty joints per week?! Who are these people? And what’s with the caveat at the end of the story? If the purpose of the study is to assess whether there might be a link between ridiculously heavy pot use and heart disease, then why not, you know, look to see whether the subjects actually suffered from heart disease? (Likely answer: Aside from the abnormal protein level, the patients were probably otherwise healthy.)
Bottom line: smoking pot all day, every day probably isn’t good for you (though I find it interesting that, even among the most prolific pot users, most of the herb’s purported dangers are either speculative or are only apparent on hyper-sensitive brain scans and multi-tiered neurocognitive tests). Fortunately, 99.9 percent of pot smokers don’t behave this way.
And no, it’s not prohibition that curbs their use habits; it’s the recognition that too much pot is not conducive to an otherwise healthy, responsible lifestyle (just as pounding five shots a day wouldn’t be conducive to, well, life).
So what lesson can be learned from the two studies above (aside from the fact that our government has no interest in investigating the health of ordinary cannabis consumers)? It’s that pot, like alcohol, is best consumed in moderation, and that pot prohibition — even when compared to the excessive use of the drug itself — still poses the greatest threat to health.
Below is this week’s summary of pending state legislation and tips to help you become involved in changing the laws in your state.
California: The state Assembly approved Assembly Bill 2279 this week by a vote of 42-29. The measure now awaits action by the Senate. If passed, AB 2279 would protect patients from employment discrimination on the basis of their state-licensed medical cannabis use in off-work hours. Californians are strongly encouraged to contact their Senators via NORML’s online advocacy system.
California: Voters in Northern California’s Mendocino County will decide on Tuesday whether or not to repeal an eight-year old county law (The Personal Use of Marijuana Initiative, also known as Measure G) which legalized the possession and use of up to 25 marijuana plants. Measure B, a Mendocino County-wide ballot initiative, seeks to overturn the measure. Activists are also challenging the validity of Measure B in court, arguing that a recent state District Court of Appeals decision prohibits municipalities from imposing limits on the quantity of marijuana patients may possess under state law. To learn more about efforts opposing Measure B, please visit California NORML or No on B.
Vermont: Legislation seeking to establish licensing procedures for state farmers who wish to commercially cultivate industrial hemp became law this week. However, as amended, House Bill 267 will not take effect until “such time as the United States Congress amends the definition of ‘marihuana.’”
North Carolina: Legislation seeking to establish a task force to study options for regulating the legal use of medical marijuana for qualified patients was introduced this week and referred to the House Committee on Health. As introduced, House Joint Resolution 2405 would “study whether a public benefit would be derived from making it lawful for physicians to prescribe and patients to possess and use marijuana.” Residents in North Carolina are strongly encouraged to contact their House Members via NORML’s online advocacy system.
“This ain’t your grandfather’s or your father’s marijuana. This will hurt you. This will addict you. This will kill you.”– Mark R. Trouville, DEA Miami, speaking to the Associated Press (June 22, 2007)
Having spent over a decade debunking the ‘potent pot myth‘ — the false yet wildly popular notion that today’s cannabis is dramatically more potent, and thus more dangerous (or as British Prime Minister Gordon Brown likes to say, “more lethal“) than the marijuana of the 1960s, 70s, and 80s, it’s nice to finally get some back up.
Writing in the forthcoming issue of the scientific journal Addiction, researchers at the University of New South Wales, National Drug and Alcohol Research Centre, examined the potency of over 100,000 pot seizures from around the word. They concluded (drum roll please), “Claims made in the public domain about a 20- or 30-fold increase in cannabis potency and about the adverse mental health effects of cannabis contamination are not supported currently by the evidence.”
The investigators also addressed the equally popular myth that ‘potent pot’ is responsible for an increase in the number of people seeking ‘treatment’ for cannabis, finding, “Another reason for increase in treatment seeking could be the introduction of cannabis diversion programmes, some of which involve mandatory treatment for those who have committed a cannabis-related offense” — a point we’ve made here on several occasions.
Want more details? NORML podcaster extraordinaire Russ Belville has an extensive summary of the study here.
Below is this week’s summary of pending state legislation and tips to help you become involved in changing the laws in your state.
Ohio: Legislation was introduced this week in the state Senate to legalize the medical use of cannabis to authorized patients. The Ohio Medical Compassion Act is modeled after existing medical cannabis laws in twelve other states. Tonya Davis of the Ohio Patient Network discusses the new bill on NORML’s Daily Audio Stashhere.
California: Legislation seeking to halt the role of state and local police in assisting in the US Justice Department in carrying out arrests and prosecutions against state-authorized medical marijuana patients and providers is scheduled for a vote by the full Assembly. As amended, Assembly Bill 2743 would prohibit state and local law inforcement personnel from “assisting in federal raids, arrests, investigations, or prosecutions [of] marijuana-related offenses … if the target is … covered under state medical marijuana laws.” A similar resolution is also pending in the Senate. Californians can support both bills via NORML’s online advocacy system.
New Jersey: The state Health Assembly Health and Senior Services Committee held an informational hearing this week on legislation that seeks to allow for the state-authorized use of medical cannabis. NORML Deputy Director Paul Armentano and NORML Legal Committee member Alan Silber both submitted testimony. New Jersey activists are encouraged to contact their state elected officials in favor of this measure by visiting NORML’s online advocacy system.
Minnesota: Minnesota Representatives adjourned this week without taking action on House File 655, which sought to authorize the medical use of cannabis by qualified patients. A companion measure had previously passed the Senate. House leadership failed to call the bill for a floor vote after promises by Gov. Tim Pawlenty that he would veto the measure. Medical marijuana proponents can contact the Governor here.
Mainstream Media is Finally Catching On Regarding Law Enforcement Excesses and Human Tragedies Associated With Cannabis Prohibition
I spoke extensively last week with Willamette Weekly’s James Pipkin and on Monday with ABC’s Marcus Baram about NORML’s monitoring and gathering case examples from around the country where medical patients, notably medical marijuana patients, are being denied organ transplants. Marcus’ and James’ articles continue to cast more needed antiseptic light on this disturbing public health practice of official discrimination against otherwise lawful medical cannabis patients.
Heads up: Additionally, the Willamette Weekly has exposed the tragedy that confronts medical patients in Oregon — that no hospital in the state will perform organ transplants on patients who test positive for cannabis, even if they are in compliance with the state’s medical marijuana laws and are in the state’s medical marijuana patient registry.
Like the recent tragedy in Tallahassee regarding the tragic death of 23-year old Rachael Hoffman resulting from her being recruited as a ’snitch’ for the local narcotic officers, the general public and maybe more importantly the general news beat media (AKA, mainstream media) have started to really bore down hard on the human tragedies that arise daily from cannabis prohibition–both in criminal enforcement of the laws, as well as how the prohibition trends upwards into important public institutions, such as in the delivery of medicine to sick, dying or sense-threatened medical patients.
Via our voices, collective consciousness and continued effective uses of employing empowering communication mediums like the Internet (i.e., webpages, podcasts, blogs, online videos and active online social networking), we can advance the long held goal and belief that an informed general public is the best path forward to ending cannabis prohibition may now finally be upon us.
I was heartened to see the Ventura Star editorialize against denying medical marijuana patients access to organ donor banks.
As the saying goes: We are the ones we’ve been waiting for!
Let’s keep the collective pressure on the media, opinion and policy-makers to replace prohibition laws with viable, and common sense-based public policy alternatives.
Forgive me if the headline above sounds slightly exploitive. My intention is not to piggyback on a personal tragedy, but I did want to get your attention.
In the fourteen years I’ve worked in marijuana law reform, few events have struck me as so needlessly tragic as the federal government’s consistent and deliberate stifling of medical cannabis research. Nowhere is the Feds’ refusal to allow this science more overt and inhumane than as it pertains to the investigation of cannabinoids as anti-cancer agents, particularly in the treatment of gliomas.
As noted in today’s wire stories regarding Senator Edward Kennedy’s diagnosis, glioma is an aggressive form of cancer that affects an estimated 10,000 Americans annually. Standard treatments for the cancer include radiation and chemotherapy, though neither procedure has proven particularly effective — with the disease killing approximately half its victims within one year and all within three years.
But what if there was an alternative treatment for gliomas that could selectively target the cancer while leaving healthy cells in tact? And what if federal bureaucrats were aware of this treatment, but deliberately withheld this information from the public?
What do you know? Drug Czar John Walters has been outed as a liar — again. I mean, seriously, let’s hope this guy is more honest when he’s filing his taxes than he is when he’s talking about pot.
The Czar’s latest reefer faux pas? According to a previous, widely distributed ONDCP press release: “Marijuana affects … many of the skills required for safe driving. … These effects can last up to 24 hours after smoking marijuana.”
Twenty-four hours, huh? Well, an Israeli investigative team recently tested Walters’ claim — giving subjects high and low doses of THC and then measuring their driving performance. Their conclusion, “No THC effects were observed after 24 hours on any of the measures.”
This finding is not to say that concerns regarding motorists — especially teens — driving after smoking marijuana are not without merit. For example, the study’s authors found that pot, even at low doses, impaired drivers’ ability to maintain lane position and significantly increased subjects’ reaction time.
Intriguingly, however, the investigators reported that marijuana’s most prominent impact on driving differed dramatically from that of alcohol.
“Average speed was the most sensitive driving performance variable affected by both THC and alcohol but with an opposite effect,” authors concluded. “In particular, subjects seemed to be aware of their impairment after THC intake and tried to compensate by driving slower; alcohol seemed to make them overly confident and caused them to drive faster than in control sessions.”
To hear my expanded thoughts on this study, check out NORML’s 5/19/08 podcast here, or download a copy of NORML’s report, “Cannabis and Driving: A Scientific and Rational Review,” available here.
What do you know? Drug Czar John Walters has been outed as a liar — 