Study: CBD Administration Associated With Improved Quality Of Life In Patients With Parkinson’s DiseaseSeptember 25, 2014
The administration of cannabidiol (CBD), a nonpsychotropic cannabinoid, is associated with improved quality of life in patients with Parkinson’s disease, according clinical trial data published online ahead of print in the Journal of Psychopharmacology.
Investigators at the University of São Paulo in Brazil assessed the efficacy of CBD versus placebo in 21 subjects with Parkinson’s. Authors reported that the administration of 300 mg doses of CBD per day was associated with “significantly different mean total scores” in subjects’ well-being and quality of life compared to placebo.
Separate assessments of CBD versus placebo reported that the cannabinoid did not appear to mitigate general symptoms of the disease, nor was it shown to be neuroprotective.
“This study points to a possible effect of CBD in improving measures related to the quality of life of PD patients without psychiatric comorbidities,” investigators concluded. They added, “We found no statistically significant differences concerning the motor symptoms of PD; however, studies involving larger samples and with systematic assessment of specific symptoms of PD are necessary in order to provide stronger conclusions regarding the action of CBD in PD.”
Clinical reports have previously indicated that both CBD and/or whole-plant cannabis may address various symptom’s of Parkinson’s disease, including improvement in motor symptoms, pain reduction, improved sleep, and a reduction in the severity of psychotic episodes.
Survey data of patients with PD indicates that almost half of all subjects who try cannabis report experiencing subjective relief from the plant.
The abstract of the study, “Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial,” appears online here.
Legalizing the retail production and sale of cannabis in the United States would yield over $3 billion in annual tax revenue, according to an analysis published this week by the personal finance website, NerdWallet.com.
Authors provided a state-by-state economic analysis, taking into account available data estimating marijuana use rates (for those age 25 and older), cannabis market size, and state and local tax rates. Researchers also assumed a flat, 15 percent excise tax on commercial marijuana production. (This excise tax rate is presently imposed in Colorado.)
Based on existing market projections, California would gain the largest amount of annual tax revenue ($519,287,052) were commercial cannabis production and sales to be legalized for adults. Other top tax revenue generating states include: New York ($248,103,676), Florida ($183,408,640), Texas ($166,303,963), and Illinois ($126,107,360).
Washington, which began allowing retail cannabis sales this summer, is estimated to reap some $119,000,000 in annual tax revenue, according to the study’s projections. Colorado, which has allowed retail cannabis sales since January 1, 2014, is estimated to gain some $78,000,000 in annual revenue.
Revenue projections for all 50 states are available online here.
Support NORML and get “Evergreen”, the exciting documentary that tells the story of how Rick Steves and friends helped legalize marijuana in Washington State
Dear NORML members and supporters,
As a board member of NORML I am feeling really good. I’m on a drug policy reform high for four reasons:
- We legalized marijuana in my state (Washington) and in Colorado in 2012. (That gives "the lower 48" a whole new meaning.) And, the Brookings Institution gave it a two-year review and concluded it’s a good thing.
- We plan to legalize in Alaska, Oregon and the District of Columbia this November. (I’ll be spending six days on a 12 city barn-storming tour in Oregon, like I did in Washington two years ago, to explain to the confused and frightened that ending this crazy prohibition of our age is good citizenship).
- There’s a great new documentary movie called "Evergreen" which tells the amazing and behind the scenes story of how a committed band of NORML-types waged our successful campaign and did what no one else until then had been able to do: make the responsible adult recreational use of marijuana a civil liberty. In my state and in Colorado now we can smoke pot just because it’s fun…we can invite our friends over and get high legally. Finally: pot is legal, taxed, and regulated. The movie tracks the political battle from start to finish and travels with me as I bring the NORML view to citizens all over the state–from churches to universities and to our capital dome. (Spoiler alert: the "rumble under the rotunda" is pretty messy.)
- And, you and your friends have a great opportunity to empower NORML to end the war on marijuana in your state too by joining or renewing your NORML membership or even joining up your mother. And, for that $50, we’ll send you a copy of the documentary movie, Evergreen.
This is important. We have momentum. There’s lots more to do. That’s why I’m donating these DVDs to NORML for this campaign. And that’s why I’m packing up and heading to Oregon next month for an intense week of media and lectures. We are a team and you matter. What are you doing? All we’re asking is that you send NORML $50. As a thanks, we’ll send you the exciting Evergreen movie.
I am so proud of what we did in Washington State. I’m proud of what NORML is doing nation-wide. And I’m really excited to offer you this movie on DVD. If you care about legalizing pot, this is something you need to watch. Share it with your friends. It’s an inspiration.
Again, to be among the first in the nation to watch Evergreen, please join NORML for $50 or more to receive your DVD copy of this important documentary capturing a historic change in American politics: When cannabis prohibition first ended.
I am contributing the cost of these DVDs to NORML as my personal challenge to you. I hope you’ll kindly join NORML, view Evergreen with friends and family, share with neighbors, co-workers and locally elected policymakers. I sincerely hope you too find the same inspiration we developed in Washington to get the job of ending marijuana prohibition done, once and for all.
Thanks in advance for your support of marijuana law reform in America and NORML’s long-standing public advocacy work.
Author and TV Host
NORML board member
Willie Nelson is a proud marijuana smoker who stopped using alcohol and tobacco decades ago. Willie, 81, credits his longevity to that decision.
Willie was purposely out of the “marijuana closet” before that became fashionable, or even politically correct. His openness came across as charmingly naive, as if he did not know cannabis was illegal, and could not figure out why others were sometimes upset.
Willie was — and still is — making a political statement that there is nothing wrong with smoking marijuana.
Two issues have always been the focus of Willie’s political attention: helping family farmers remain on the land and legalizing marijuana.
Willie and I have frequently talked over the years about the natural crossover between those two issues. If marijuana were legal for American farmers to cultivate and sell, tens of thousands of family farmers could grow marijuana and financially thrive and remain on the land, continuing the great rural tradition dating back to the founding of our country.
Among those voters age 18 to 40, 47 percent ranked alcohol as the most harmful substance to society, well ahead of both tobacco (27 percent) and cannabis (13 percent). (Thirteen percent of respondents were undecided.) Respondents among all age and ethnic groups were consistent in ranking marijuana as the least harmful of the three substances, as were self-identified Democrats and Independents. (Republicans rated tobacco to be the most harmful of the three products.)
“[These] numbers suggest younger Americans are upending societal conventions, which have long seen alcohol as an acceptable drug while condemning marijuana,” stated Rare.us in an accompanying press release.
The results are somewhat similar to those of a Wall Street Journal/NBC News poll released in March which reported that most Americans believe tobacco to be most harmful to health (49 percent), followed by alcohol (24 percent), sugar (15 percent), and marijuana (8 percent).
Under federal law, marijuana is classified as a schedule I controlled substance, meaning that its alleged harms are equal to those of heroin. Both tobacco and alcohol are unscheduled under federal law.
According to a study published in 2004 in the Journal of the American Medical Association, the leading causes of death in the United States ware tobacco (435,000 deaths; 18.1 percent of total US deaths), poor diet and physical inactivity (365,000 deaths; 15.2 percent), and alcohol consumption (85,000 deaths; 3.5 percent).