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agonists

  • by Paul Armentano, NORML Deputy Director March 1, 2011

    The United States Drug Enforcement Administration (DEA) today, as anticipated, exercised its ‘emergency scheduling authority’ to criminally prohibit the possession and sale of chemical agents contained in so-called ‘fake’ herbal marijuana products, commonly sold over the counter under the brand names ‘K2’ and ‘Spice.’ The agency had initially announced its intent to outlaw the chemicals last November.

    The specific compounds prohibited under the new DEA ban are: JWH-018, JWH-073, JWH-200, CP-47,497, and cannabicyclohexanol. Each of these compounds is now placed in the same category as heroin under federal law.

    “Except as authorized by law, this action makes possessing and selling these chemicals or the products that contain them illegal in the United States,” the DEA stated in a press release. “This emergency action was necessary to prevent an imminent threat to public health and safety.”

    The agency says that the federal ban will remain in effect for at least one year while the DEA and the United States Department of Health and Human Services (DHHS) “further study whether these chemicals should be permanently controlled.”

    The chemicals in question are synthetic cannabinoid agonists. Once ingested, they interact with endogenous cannabinoid receptors to elicit certain physical and euphoric effects associated with the ingestion of marijuana. They are added to inert herbs to temporarily induce euphoria in the user.

    Though NORML takes no official position regarding the use or regulation of these synthetic products, NORML Deputy Director Paul Armentano issued the following statement:

    “The popularity of these products is a predictable outgrowth of criminal marijuana prohibition. As prohibition is apt to do, it has driven the production of a commodity into the hands of unregulated, unknown dealers, driven up the potency of the commodity, and in doing so created a scenario where the consumer is faced with a potentially greater health risks than they would be had they simply had the legal choice to use the product they actually desired, in this case cannabis.

    “Since most manufacturers of these products reside overseas and are not subject to federal laws and regulations, it is unlikely that the DEA’s action – as well as the similar bans in other states – will in any way halt the dissemination, use, or misuse of these products by the public. Most likely, the clamp down will likely only make the situation more dangerous – from both a legal standpoint and from a health standpoint – to the consumer.

  • by Paul Armentano, NORML Deputy Director August 18, 2009

    UPDATE!!! UPDATE!!!

    The MSM may be starting to pay attention. I just got off the phone with CBS News radio, who will be covering this story imminently.

    It was just yesterday that I was lamenting about the mainstream media’s failure to report on the anti-cancer properties of cannabis. And then along comes Reuters with this:

    Cannabis chemicals may help fight prostate cancer
    via Reuters News Wire

    Chemicals in cannabis have been found to stop prostate cancer cells from growing in the laboratory, suggesting that cannabis-based medicines could one day help fight the disease, scientists said Wednesday.

    After working initially with human cancer cell lines, Ines Diaz-Laviada and colleagues from the University of Alcala in Madrid also tested one compound on mice and discovered it produced a significant reduction in tumor growth.

    Their research, published in the British Journal of Cancer, underlines the growing interest in the medical use of active chemicals called cannabinoids, which are found in marijuana.

    Experts, however, stressed that the research was still exploratory and many more years of testing would be needed to work out how to apply the findings to the treatment of cancer in humans.

    “This is interesting research which opens a new avenue to explore potential drug targets but it is at a very early stage,” said Lesley Walker, director of cancer information at Cancer Research UK, which owns the journal.

    It absolutely isn’t the case that men might be able to fight prostate cancer by smoking cannabis,” she added.

    Well, well, well, leave it to the MSM to misrepresent the facts and miss the real story. First, the chemicals assessed in this study, R(+)-Methanandamide and JWH-015, are neither “cannabinoids” nor are they “chemicals in cannabis.” Rather, they are synthetic, selective CB2 receptor agonists. In short, they are chemicals created in a lab to mimic certain elements in marijuana, and to bind to specifically to those cannabinoid receptors that are not located in the brain. After all, we can’t possibly have the terminally ill feeling ‘better’, now can we?

    Second, US federal researchers have known for some 35 years that the naturally occurring chemicals in cannabis — not just synthesized agonists — can halt the proliferation of multiple types of cancer, including including brain cancer, prostate cancer, breast cancer, lung cancer, skin cancer, and pancreatic cancer. We even know how.

    Cannabinoids: potential anticancer agents
    via Nature Reviews Cancer (2003)

    Cannabinoids are usually well tolerated, and do not produce the generalized toxic effects of conventional chemotherapies. … Cannabinoids inhibit tumor growth in laboratory animals. They do so by modulating key cell-signaling pathways, thereby inducing direct growth arrest and death of tumor cells, as well as by inhibiting tumor angiogenesis and metastasis. Cannabinoids are selective anti-tumor compounds, as they can kill tumor cells without affecting their non-transformed counterparts.

    Of course, the real question — conveniently ignored by Reuters and the rest of the MSM — is this: Why, after three decades and dozens of preclinical trials documenting cannabis’ potent anti-cancer abilities, are “many more years of testing” necessary? Last I checked, humans die en masse from cancer, not rats! Yet for some 35 years scientists have been content to replicate these  cancer-killer findings in animals and in petri dishes, all the while warning, “It absolutely isn’t the case that men might be able to fight prostate cancer by smoking cannabis.”

    Well why the hell not? Not only can cannabis alleviate cancer patients’ nausea and pain, elevate their mood, and increase their appetite, but also — as dozens of preclinical trials over the past three decades consistently demonstrate — marijuana may help to alleviate the very disease that’s ravaging their bodies. Of course, rather than put this theory to the test, investigators for more than three decades have been willing to let people with a terminal illness die while they piddle around with their petri dishes. And to date, not one reporter from the mainstream media has ever had the guts to ask them why.