[Editor's note: This post is excerpted from this week's forthcoming NORML weekly media advisory. To have NORML's media advisories and legislative updates delivered straight to your in-box, sign up for 'NORML News' here. To read more about the anticancer properties of cannabinoids, please see NORML's literature review here.]
Cannabis inhalation is associated with spontaneous brain tumor regression in two subjects, according to a pair of case reports to be published in Child’s Nervous System, the official journal of the International Society for Pediatric Neurosurgery.
Investigators at the British Columbia Children’s Hospital in Vancouver documented the mitigation of residual tumors in two adolescent subjects who regularly inhaled cannabis. Authors determined that both subjects experienced a “clear regression” of their residual brain tumors over a three-year-period.
“Neither patient received any conventional adjuvant treatment” during this time period, investigators wrote. “The tumors regressed over the same period of time that cannabis was consumed via inhalation, raising the possibility that cannabis played a role in tumor regression.”
Researchers concluded, “Further research may be appropriate to elucidate the increasingly recognized effect of cannabis/cannabinoids on gliomas (brain cancers).”
A 2006 pilot study published in the British Journal of Cancer previously reported that the intratumoral administration of the cannabinoid THC was associated with reduced tumor cell proliferation in two of nine human subjects with brain cancer.
Separate preclinical studies assessing the anticancer activity of cannabinoids and endocannabinoids indicate that the substances can inhibit the proliferation of various types of cancerous cells, including breast carcinoma, prostate carcinoma, and lung cancer.
Commenting on the two new case reports, researcher Jahan Marcu — who has previously documented the inhibitory effects of cannabinoids on human glioblastoma cell proliferation and survival — wrote in the blog Freedom Is Green: “Can marijuana contribute to the regression or remission of certain cancers? Given the slow progress of clinical trials for whole plant Cannabis, it can be frustrating waiting for years, even decades, trying to answer these vital questions. But for the two young women with brain cancer in (this) report, a shift to a cannabis lifestyle may have made a difference.”
From Reuters News Wire:
Alcohol kills more than AIDS, TB or violence
Drinking causes more than 4 percent of deaths worldwide, WHO warns
Alcohol causes nearly 4 percent of deaths worldwide, more than AIDS, tuberculosis or violence, the World Health Organization warned on Friday.
… Yet alcohol control policies are weak and remain a low priority for most governments despite drinking’s heavy toll on society from road accidents, violence, disease, child neglect and job absenteeism, it said.
Approximately 2.5 million people die each year from alcohol related causes, the WHO said in its “Global Status Report on Alcohol and Health.”
“The harmful use of alcohol is especially fatal for younger age groups and alcohol is the world’s leading risk factor for death among males aged 15-59,” the report found.
… Alcohol is a causal factor in 60 types of diseases and injuries, according to WHO’s first report on alcohol since 2004.
Its consumption has been linked to cirrhosis of the liver, epilepsy, poisonings, road traffic accidents, violence, and several types of cancer, including cancers of the colorectum, breast, larynx and liver
Of course the reason we see these startling links between alcohol consumption and disease is because ethanol, the psychoactive compound in alcohol, and acetaldehyde (what ethanol is converted to after ingestion), pose toxic risks to health cells and organs. By contrast, marijuana’s active compounds — the cannabinoids — pose little comparable risk to healthy cells and organs, and are incapable of causing fatal overdose.
NORML has recently posted online the fourth edition of its popular and comprehensive booklet, “Emerging Clinical Applications for Cannabis & Cannabinoids: A Review of the Recent Scientific Literature.”
Updated and revised for 2011, this report reviews approximately 200 newly published scientific studies assessing the safety and efficacy of marijuana and its compounds in the treatment and management of nineteen clinical indications: Alzheimer’s disease, Amyotrophic Lateral Sclerosis (ALS), chronic pain, diabetes mellitus, dystonia, fibromyalgia, gastrointestinal disorders, gliomas and other cancers, hepatitis C, human immunodeficiency virus (HIV), hypertension, incontinence, methicillin-resistant Staphyloccus aureus (MRSA), multiple sclerosis, osteoporosis, pruritus, rheumatoid arthritis, sleep apnea, and Tourette’s syndrome.
Explains the report’s lead author, NORML Deputy Director Paul Armentano: “The conditions profiled in this report were chosen because patients frequently inquire about the therapeutic use of cannabis to treat these disorders. In addition, many of the indications included in this report may be moderated by cannabis therapy. In several cases, preclinical data and clinical data indicates that cannabinoids may halt the progression of these diseases in a more efficacious manner than available pharmaceuticals.”
The updated report also features a new section, authored by osteopath and medical cannabis specialist Dr. Dustin Sulak, highlighting the significance of the endocannabinoid system and its role in maintaining mental and physiological health.
“As we continue to sort through the emerging science of cannabis and cannabinoids, one thing remains clear: a functional cannabinoid system is essential for health,” writes Dr. Sulak. “From embryonic implantation on the wall of our mother’s uterus, to nursing and growth, to responding to injuries, endocannabinoids help us survive in a quickly changing and increasingly hostile environment. As I realized this, I began to wonder: can an individual enhance his/her cannabinoid system by taking supplemental cannabis? Beyond treating symptoms, beyond even curing disease, can cannabis help us prevent disease and promote health by stimulating an ancient system that is hard-wired into all of us? I now believe the answer is yes.”
Full text of the report is now available online here. Hard copies will be available for purchase shortly. Print copies of the third edition of this report will be made available at a reduced rate for those seeking bulk orders. (Please e-mail NORML for further details.)
Now Dr. Andrew Weil, a best-selling author and world-renowned leader and pioneer in the field of integrative medicine, has lent his powerful voice to this discussion.
Cannabis Rx: Cutting Through the Misinformation
via Huffington Post
[Excerpt below; read the full commentary here.] Research into possible medical uses of cannabis is enjoying a renaissance. In recent years, studies have shown potential for treating nausea, vomiting, premenstrual syndrome, insomnia, migraines, multiple sclerosis, spinal cord injuries, alcohol abuse, collagen-induced arthritis, asthma, atherosclerosis, bipolar disorder, depression, Huntington’s disease, Parkinson’s disease, sickle-cell disease, sleep apnea, Alzheimer’s disease and anorexia nervosa.
But perhaps most exciting, cannabinoids (chemical constituents of Cannabis, the best known being tetrahydrocannabinol or THC) may have a primary role in cancer treatment and prevention. A number of studies have shown that these compounds can inhibit tumor growth in laboratory animal models. In part, this is achieved by inhibiting angiogenesis, the formation of new blood vessels that tumors need in order to grow. What’s more, cannabinoids seem to kill tumor cells without affecting surrounding normal cells. If these findings hold true as research progresses, cannabinoids would demonstrate a huge advantage over conventional chemotherapy agents, which too often destroy normal cells as well as cancer cells.
As long ago as 1975, researchers reported that cannabinoids inhibited the growth of a certain type of lung cancer cell in test tubes and in mice. Since then, laboratory studies have shown that cannabinoids have effects against tumor cells from glioblastoma (a deadly type of brain cancer) as well as those from thyroid cancer¸ leukemia/lymphoma, and skin, uterus, breast, stomach, colorectal, pancreatic and prostate cancers.
… If you want to learn more about this subject, I recommend an excellent documentary film, “What If Cannabis Cured Cancer,” by Len Richmond, which summarizes the remarkable research findings of recent years. Most medical doctors are not aware of this information and its implications for cancer prevention and treatment. The film presents compelling evidence that our current policy on cannabis is counterproductive.
At this past weekend’s national NORML Conference, several panelists — myself included — discussed the use of cannabinoids as selective anti-cancer agents. We also screened Len Richmond’s excellent documentary (in which I’m briefly interviewed) “What If Cannabis Cured Cancer?” (Watch the movie trailer here.)
Fortunately, this important discussion is just now finally making its way into the mainstream. Unfortunately, it’s taken 30+ years to get the MSM to notice.
What possible advancements in the treatment of cancer may have been achieved over the past three decades had U.S. government officials chosen to advance — rather than suppress — clinical research into the anti-cancer effects of cannabis? It’s time for the public and the media to demand an answer.
Investigators and pundits alike are fond of calling for ‘more research’ into the safety and efficacy of marijuana and its active compounds. Ironically, when such calls are heeded and new research is published, nobody wants to talk about it.
For example, researchers at the State University of New York (SUNY), Upstate Medical University in Syracuse published data in the June issue of the journal Pharmacology concluding that the administration of the plant cannabinoids delta-8-THC and delta-9-THC halted cellular respiration and tumor growth in human oral cancer cells. Specifically, investigators reported that cannabinoids were a “potent inhibitor” of Tu183 human cancer cells, a notoriously difficult to treat type of oral cancer.
Of course, this is hardly the first time that pot’s compounds have been demonstrated to possess anti-cancer properties. As has been widely reported here and elsewhere, US government researchers were first aware of this finding over 35 years ago, and today there exist published scientific studies demonstrating that cannabinoids can inhibit the proliferation of a wide range of cancers — including brain cancer, prostate cancer, breast cancer, lung cancer, skin cancer, pancreatic cancer, biliary tract cancer, and lymphoma. Nonetheless, abstract prohibitionist concerns regarding marijuana’s supposed cancer risk continue to dominate the headlines while actual scientific studies debunking these allegations tend to go unnoticed.
Similarly, preclinical data published online last week in the journal Cell Communication and Signaling reported that the administration of the non-psychoactive cannabinoid cannabidiol (CBD) increases adult neurogenesis (the active production of new neurons) in laboratory animals. Authors speculated that cannabis’ pro-neurogenic effects may explain why the plant appears to be useful in the treatment of certain neurodegenerative disorders like Alzheimer’s disease or ALS.
As I wrote last week, to date there are now over 20,000 published studies or reviews in the scientific literature pertaining to marijuana and its active compounds — making marijuana the most studied plant on Earth. But what’s the point in further research if nobody even bothers to pay attention to the research that’s already been done?