Cannabis Inhalation Associated With Spontaneous Tumor Regression, Study Says

[Editor's note: This post is excerpted from this week's forthcoming NORML weekly media advisory. To have NORML's media advisories and legislative updates delivered straight to your in-box, sign up for 'NORML News' here. To read more about the anticancer properties of cannabinoids, please see NORML's literature review here.]

Cannabis inhalation is associated with spontaneous brain tumor regression in two subjects, according to a pair of case reports to be published in Child’s Nervous System, the official journal of the International Society for Pediatric Neurosurgery.

Investigators at the British Columbia Children’s Hospital in Vancouver documented the mitigation of residual tumors in two adolescent subjects who regularly inhaled cannabis. Authors determined that both subjects experienced a “clear regression” of their residual brain tumors over a three-year-period.

“Neither patient received any conventional adjuvant treatment” during this time period, investigators wrote. “The tumors regressed over the same period of time that cannabis was consumed via inhalation, raising the possibility that cannabis played a role in tumor regression.”

Researchers concluded, “Further research may be appropriate to elucidate the increasingly recognized effect of cannabis/cannabinoids on gliomas (brain cancers).”

A 2006 pilot study published in the British Journal of Cancer previously reported that the intratumoral administration of the cannabinoid THC was associated with reduced tumor cell proliferation in two of nine human subjects with brain cancer.

Separate preclinical studies assessing the anticancer activity of cannabinoids and endocannabinoids indicate that the substances can inhibit the proliferation of various types of cancerous cells, including breast carcinoma, prostate carcinoma, and lung cancer.

Commenting on the two new case reports, researcher Jahan Marcu — who has previously documented the inhibitory effects of cannabinoids on human glioblastoma cell proliferation and survival — wrote in the blog Freedom Is Green: “Can marijuana contribute to the regression or remission of certain cancers? Given the slow progress of clinical trials for whole plant Cannabis, it can be frustrating waiting for years, even decades, trying to answer these vital questions. But for the two young women with brain cancer in (this) report, a shift to a cannabis lifestyle may have made a difference.”

Updated NORML Report Reviews Nearly 200 Studies On The Therapeutic Use Of Cannabis

NORML has recently posted online the fourth edition of its popular and comprehensive booklet, “Emerging Clinical Applications for Cannabis & Cannabinoids: A Review of the Recent Scientific Literature.”

Updated and revised for 2011, this report reviews approximately 200 newly published scientific studies assessing the safety and efficacy of marijuana and its compounds in the treatment and management of nineteen clinical indications: Alzheimer’s disease, Amyotrophic Lateral Sclerosis (ALS), chronic pain, diabetes mellitus, dystonia, fibromyalgia, gastrointestinal disorders, gliomas and other cancers, hepatitis C, human immunodeficiency virus (HIV), hypertension, incontinence, methicillin-resistant Staphyloccus aureus (MRSA), multiple sclerosis, osteoporosis, pruritus, rheumatoid arthritis, sleep apnea, and Tourette’s syndrome.

Explains the report’s lead author, NORML Deputy Director Paul Armentano: “The conditions profiled in this report were chosen because patients frequently inquire about the therapeutic use of cannabis to treat these disorders. In addition, many of the indications included in this report may be moderated by cannabis therapy. In several cases, preclinical data and clinical data indicates that cannabinoids may halt the progression of these diseases in a more efficacious manner than available pharmaceuticals.”

The updated report also features a new section, authored by osteopath and medical cannabis specialist Dr. Dustin Sulak, highlighting the significance of the endocannabinoid system and its role in maintaining mental and physiological health.

“As we continue to sort through the emerging science of cannabis and cannabinoids, one thing remains clear: a functional cannabinoid system is essential for health,” writes Dr. Sulak. “From embryonic implantation on the wall of our mother’s uterus, to nursing and growth, to responding to injuries, endocannabinoids help us survive in a quickly changing and increasingly hostile environment. As I realized this, I began to wonder: can an individual enhance his/her cannabinoid system by taking supplemental cannabis? Beyond treating symptoms, beyond even curing disease, can cannabis help us prevent disease and promote health by stimulating an ancient system that is hard-wired into all of us? I now believe the answer is yes.”

Full text of the report is now available online here. Hard copies will be available for purchase shortly. Print copies of the third edition of this report will be made available at a reduced rate for those seeking bulk orders. (Please e-mail NORML for further details.)

Still More On Cannabis, Cancer, And The Ongoing Federal Suppression Of Research

For over a decade now I’ve been telling folks that compounds in cannabis can selectively target and kill malignant cancer cells. It seems like some media outlets finally starting to get the message.

Today, the good folks at HuffingtonPost.com published my latest essay on the subject, “What Your Government Knows About Cannabis And Cancer — And Isn’t Telling You.”

Since the Huffington Post is an online medium, I made it a point to include nearly a dozen links to pertinent research and clinical/pre-clinical trials demonstrating that cannabinoids possess anti-cancer properties.

Fortunately, in the past 10 years scientists overseas have generously picked up where U.S. researchers so abruptly left off, reporting that cannabinoids can halt the spread of numerous cancer cells — including prostate cancer, breast cancer, lung cancer, pancreatic cancer, and brain cancer. (An excellent paper summarizing much of this research, “Cannabinoids for Cancer Treatment: Progress and Promise,” appears in the January 2008 edition of the journal Cancer Research.) A 2006 patient trial published in the British Journal of Cancer even reported that the intracranial administration of THC was associated with reduced tumor cell proliferation in humans with advanced glioblastoma.

For most visitors to the Huffington Post, my essay will be their first exposure to this information, but ideally, not their last. Hopefully, readers of the site — which is one of the most visited on the Internet — will join us in our calls to end the US government’s multi-decade long denial of this potentially groundbreaking research.

You can read the full text of my essay here.

Please feel free to leave a comment and/or circulate this article widely (Digg it, reddit, buzz up, etc.) My last Huff Post essay, “Don’t Buy The ‘Potent Pot’ Hype,” received nearly 100 comments, a personal response from the Drug Czar’s office, and earned me a guest spot on Dr. Drew Pinsky’s live nationally syndicated radio show. That said, in my opinion, the government’s cover-up of pot’s anti-cancer abilities is a far more important topic; hopefully we can get a similar buzz started.

PS: Those interested in learning more about this topic can download an audio file of my recent guest appearance on the radio show, “Sex, Drugs, and Civil Liberties,” (KOPN: Columbia, Missouri) here.

Cannabis, Cancer, And The Ongoing Federal Suppression Of Research (Part 3)

I’m proud to be a guest on this week’s edition of KPFT’s Century of Lies radio program to discuss the therapeutic use of cannabis and the federal government’s multi-decade campaign to suppress research documenting its clinical utility. You can listen to the radio show online here.

You can also watch a separate interview with me discussing the anti-cancer properties of pot, and join the ongoing discussion on Alternet.org here.

Cannabis, Cancer, And The Ongoing Federal Suppression Of Research (Part 2)

Following yesterday’s blog post regarding the use of cannabinoids as potential treatment agents for gliomas, the good folks at Cannabis TV have made available a short video presentation on the subject.

The following interview took place this past April, just prior to my presentation at the Fifth National Clinical Conference on Cannabis Therapeutics.