Cannabis inhalation is associated with spontaneous brain tumor regression in two subjects, according to a pair of case reports to be published in Child’s Nervous System, the official journal of the International Society for Pediatric Neurosurgery.

Investigators at the British Columbia Children’s Hospital in Vancouver documented the mitigation of residual tumors in two adolescent subjects who regularly inhaled cannabis. Authors determined that both subjects experienced a “clear regression” of their residual brain tumors over a three-year-period.

“Neither patient received any conventional adjuvant treatment” during this time period, investigators wrote. “The tumors regressed over the same period of time that cannabis was consumed via inhalation, raising the possibility that cannabis played a role in tumor regression.”

Researchers concluded, “Further research may be appropriate to elucidate the increasingly recognized effect of cannabis/cannabinoids on gliomas (brain cancers).”

A 2006 pilot study published in the British Journal of Cancer previously reported that the intratumoral administration of the cannabinoid THC was associated with reduced tumor cell proliferation in two of nine human subjects with brain cancer.

Separate preclinical studies assessing the anticancer activity of cannabinoids and endocannabinoids indicate that the substances can inhibit the proliferation of various types of cancerous cells, including breast carcinoma, prostate carcinoma, and lung cancer.

Commenting on the two new case reports, researcher Jahan Marcu — who has previously documented the inhibitory effects of cannabinoids on human glioblastoma cell proliferation and survival — wrote in the blog Freedom Is Green: “Can marijuana contribute to the regression or remission of certain cancers? Given the slow progress of clinical trials for whole plant Cannabis, it can be frustrating waiting for years, even decades, trying to answer these vital questions. But for the two young women with brain cancer in (this) report, a shift to a cannabis lifestyle may have made a difference.”

Updated and revised for 2011, this report reviews approximately 200 newly published scientific studies assessing the safety and efficacy of marijuana and its compounds in the treatment and management of nineteen clinical indications: Alzheimer’s disease, Amyotrophic Lateral Sclerosis (ALS), chronic pain, diabetes mellitus, dystonia, fibromyalgia, gastrointestinal disorders, gliomas and other cancers, hepatitis C, human immunodeficiency virus (HIV), hypertension, incontinence, methicillin-resistant Staphyloccus aureus (MRSA), multiple sclerosis, osteoporosis, pruritus, rheumatoid arthritis, sleep apnea, and Tourette’s syndrome.

Explains the report’s lead author, NORML Deputy Director Paul Armentano: “The conditions profiled in this report were chosen because patients frequently inquire about the therapeutic use of cannabis to treat these disorders. In addition, many of the indications included in this report may be moderated by cannabis therapy. In several cases, preclinical data and clinical data indicates that cannabinoids may halt the progression of these diseases in a more efficacious manner than available pharmaceuticals.”

The updated report also features a new section, authored by osteopath and medical cannabis specialist Dr. Dustin Sulak, highlighting the significance of the endocannabinoid system and its role in maintaining mental and physiological health.

“As we continue to sort through the emerging science of cannabis and cannabinoids, one thing remains clear: a functional cannabinoid system is essential for health,” writes Dr. Sulak. “From embryonic implantation on the wall of our mother’s uterus, to nursing and growth, to responding to injuries, endocannabinoids help us survive in a quickly changing and increasingly hostile environment. As I realized this, I began to wonder: can an individual enhance his/her cannabinoid system by taking supplemental cannabis? Beyond treating symptoms, beyond even curing disease, can cannabis help us prevent disease and promote health by stimulating an ancient system that is hard-wired into all of us? I now believe the answer is yes.”

Full text of the report is now available online here. Hard copies will be available for purchase shortly. Print copies of the third edition of this report will be made available at a reduced rate for those seeking bulk orders. (Please e-mail NORML for further details.)

Today, the good folks at HuffingtonPost.com published my latest essay on the subject, “What Your Government Knows About Cannabis And Cancer — And Isn’t Telling You.”

Since the Huffington Post is an online medium, I made it a point to include nearly a dozen links to pertinent research and clinical/pre-clinical trials demonstrating that cannabinoids possess anti-cancer properties.

Fortunately, in the past 10 years scientists overseas have generously picked up where U.S. researchers so abruptly left off, reporting that cannabinoids can halt the spread of numerous cancer cells — including prostate cancer, breast cancer, lung cancer, pancreatic cancer, and brain cancer. (An excellent paper summarizing much of this research, “Cannabinoids for Cancer Treatment: Progress and Promise,” appears in the January 2008 edition of the journal Cancer Research.) A 2006 patient trial published in the British Journal of Cancer even reported that the intracranial administration of THC was associated with reduced tumor cell proliferation in humans with advanced glioblastoma.

For most visitors to the Huffington Post, my essay will be their first exposure to this information, but ideally, not their last. Hopefully, readers of the site — which is one of the most visited on the Internet — will join us in our calls to end the US government’s multi-decade long denial of this potentially groundbreaking research.

You can read the full text of my essay here.

Please feel free to leave a comment and/or circulate this article widely (Digg it, reddit, buzz up, etc.) My last Huff Post essay, “Don’t Buy The ‘Potent Pot’ Hype,” received nearly 100 comments, a personal response from the Drug Czar’s office, and earned me a guest spot on Dr. Drew Pinsky’s live nationally syndicated radio show. That said, in my opinion, the government’s cover-up of pot’s anti-cancer abilities is a far more important topic; hopefully we can get a similar buzz started.

PS: Those interested in learning more about this topic can download an audio file of my recent guest appearance on the radio show, “Sex, Drugs, and Civil Liberties,” (KOPN: Columbia, Missouri) here.

You can also watch a separate interview with me discussing the anti-cancer properties of pot, and join the ongoing discussion on Alternet.org here.

The following interview took place this past April, just prior to my presentation at the Fifth National Clinical Conference on Cannabis Therapeutics.

In the fourteen years I’ve worked in marijuana law reform, few events have struck me as so needlessly tragic as the federal government’s consistent and deliberate stifling of medical cannabis research. Nowhere is the Feds’ refusal to allow this science more overt and inhumane than as it pertains to the investigation of cannabinoids as anti-cancer agents, particularly in the treatment of gliomas.

As noted in today’s wire stories regarding Senator Edward Kennedy’s diagnosis, glioma is an aggressive form of cancer that affects an estimated 10,000 Americans annually. Standard treatments for the cancer include radiation and chemotherapy, though neither procedure has proven particularly effective — with the disease killing approximately half its victims within one year and all within three years.

But what if there was an alternative treatment for gliomas that could selectively target the cancer while leaving healthy cells in tact? And what if federal bureaucrats were aware of this treatment, but deliberately withheld this information from the public?

Sadly, the above questions are not hypothetical. As I originally wrote in 2004 essay for Alternet.org, entitled “Pot Shows Promise as a Cancer Cure”

In fact, the first experiment documenting pot’s anti-tumor effects took place in 1974 at the Medical College of Virginia at the behest of the U.S. government. The results of that study, reported in an Aug. 18, 1974, Washington Post newspaper feature, were that marijuana’s psychoactive component, THC, “slowed the growth of lung cancers, breast cancers and a virus-induced leukemia in laboratory mice, and prolonged their lives by as much as 36 percent.”

Despite these favorable preliminary findings, U.S. government officials banished the study, and refused to fund any follow-up research until conducting a similar – though secret – clinical trial in the mid-1990s. That study, conducted by the U.S. National Toxicology Program to the tune of $2 million concluded that mice and rats administered high doses of THC over long periods had greater protection against malignant tumors than untreated controls.

However, rather than publicize their findings, government researchers shelved the results, which only became public after a draft copy of its findings were leaked in 1997 to a medical journal which in turn forwarded the story to the national media.

In the years since the completion of the National Toxicology trial, the U.S. government has yet to fund a single additional study examining the drug’s potential anti-cancer properties. Is this a case of federal bureaucrats putting politics over the health and safety of patients? You be the judge.

Fortunately, in the past ten years scientists overseas have generously picked up where U.S. researchers so abruptly left off, reporting that cannabinoids can halt the spread of numerous cancer cells — including prostate cancer, breast cancer, lung cancer, pancreatic cancer, and in one human clinical trial, brain cancer.

Writing earlier this year in the journal Expert Review of Neurotherapeutics, Italian researchers reiterated, “[C]annabinoids have displayed a great potency in reducing glioma tumor growth either in vitro or in animal experimental models. … [They] appear to be selective antitumoral agents as they kill glioma cells without affecting the viability of nontransformed counterparts.” Not one mainstream media outlet reported their findings. Perhaps now they’ll pay better attention.

What possible advancements in the treatment of cancer may have been achieved over the past 34 years had US government officials chosen to advance — rather than suppress — clinical research into the anti-cancer effects of cannabis? It’s a shame we have to speculate; it’s even more tragic that the families of Senator Kennedy and thousands of others must suffer while we do.