Loading

Marinol

  • by Russ Belville, NORML Outreach Coordinator October 24, 2011

    Gallup Polls Support and Opposition to Marijuana Legalization 1969-2011

    As 50% of Americans now support marijuana legalization, the prohibitionists are coming out in full force with hysterical propaganda to once again terrorize voters about cannabis.  We intended to scour multiple sources to compile the five most common scare tactics they use, but Joseph Summerill, director of the Summerill Group LLC, a Washington, D.C.- based law enforcement think tank and general counsel for the Major County Sheriffs’ Association, made our job easy by using all five in one op-ed piece published today in the Washington Examiner entitled, “Facts on medical marijuana are stubborn things, too“.

    Lie #1) Marijuana’s not really medical.  The government says so!

    [M]arijuana is a Schedule I drug… a high potential for abuse or dependency… no accepted medical value… unsafe to use, even under medical supervision.  [M]arijuana has not passed the rigid scrutiny of medicine proposed by the FDA.

    The Truth

    (more…)

  • by Allen St. Pierre, NORML Executive Director February 21, 2010

    Where Do You Get ‘It’ From?

    Author: Publius*

    Most patients don’t get asked where they get their medicine. That’s because everyone knows people get their medicine from a pharmacy. But I have to get my medicine otherwise. I have to safeguard my “source” because my medicine is cannabinoid based – and that makes it almost illegal.  – But not today.  Today I can answer the source question openly because it is my local pharmacy – with drive-thru service and open to dispense medicine 24 hours a day. I drive up and push a big, yellow smiley-faced button to gain access – a soft automated voice comes over the speaker to verify that I am in the right place in order to pick up my prescription. Next, the typical professional looking person – white coat with badge – slides open the window asking my name and what I need.

    “I’m picking up a prescription for Publius.”

    They return with a baggie and bottle containing 30 synthetic cannabinoid capsules dosed at 5mg each – that’s right, legal cannabinoids!

    What are cannabinoids? Well, here is where things get interesting. As one learns in biology, the human body has many systems – the circulatory, respiratory, digestive, and nervous systems to name a few. Each system has parts: for example, the nervous system is made up of the brain, spinal cord, and nerves. By the late 1980s, science identified a new human system – the endocannabinoid system (ECS) – also referred to as the cannabinoid system. There is a cannabinoid system present in all mammals – to include humans and 15,000 other species.  A mammal is any vertebrate animal distinguished by self-regulating body temperature, hair, and milk-producing females – as mammal means “breast” or of the breast.

    The ECS has two main parts: cannabinoids, which are chemical neurotransmitters, and two receptors called “CB1″ and “CB2.” Cannabinoids activate receptors found throughout the body – in all organs, for example. In fact, all systems in our bodies are modulated by the cannabinoid system. This means that as a body system changes, it uses the ECS to do so.

    Science and popular search sites like Wikipedia use three classifications of cannabinoids:

    1.  Endogenous cannabinoids (also referred to as endocannabinoids), which are produced by the human body

    2.  Herbal cannabinoids, the kind found in the cannabis sativa plant

    3.  Synthetic cannabinoids, produced and distributed by pharmaceutical companies

    The third kind is what I am picking up from the pharmacy – 30 Marinol (Dronabinol) capsules. Marinol is a prescribed cannabinoid from my doctor – and I am going to test it against the herbal cannabinoids I have been baking into my brownies for five years now.

    The pharmacist hands me a white paper bag containing the Marinol prescribed for my Multiple Sclerosis (MS). Stapled to the top is a typical handout with cautionary medical information. The small amount (150mg) of the synthetic cannabinoid THC costs $370 – or more than $69,000 per ounce!

    I sign my name on a distribution sheet and pay my $3 Medicare co-pay. The government, meaning our tax dollars, pays the other $367 for my medicine.  Now I am ready to go – but not before my ‘synthetic cannabinoid’ dealer informs me of possible side effects. She warns me to be on the lookout for – “dizziness, drowsiness, confusion, feeling ‘high,’ an exaggerated sense of well-being, lightheadedness, headache, red eyes, dry mouth, nausea, vomiting, stomach pain, clumsiness, or unsteadiness.”

    Geez – sounds like a lot of potential adversity on my chemically sensitive body.  From personal experience, I know that the herbal cannabinoids do not cause these side effects in my body. The pharmacist did mention one noticeable side effect that I have had with eating cannabis brownies: dry mouth – which is hardly a problem when considering the overall benefits of the medicine.

    When I get home I open the bag to take a look at the Marinol. The pills are a deep maroon color and perfectly round. They remind me of Boston Baked Beans – as they look exactly like those candies. One thing is for sure: synthetic cannabinoids do not look anything like herbal cannabinoids – the ones from the plant itself. The distinct medical difference of popping pills versus the variations and qualities of consuming natural cannabis cannot be understated – and surely won’t be by me. After a week of taking one pill a night before bed, as the doctor prescribed, I do not notice any positive effects from the Marinol. It makes me hungry – but that was never a problem in the first place. However, it is my first legal cannabinoid and that is what counts, right? – Not whether it works, just whether it is legal, right?

    Wrong.

    Here is what I know.  I have been self-medicating with herbal cannabinoids for five years to provide relief from MS, which I have had for 23 years.  During that time I went through the long list of prescribed pharmaceuticals.  The relief was minimal. The problem was (and is) the side effects, which became unbearable over time. I felt like a slave, dependent on a cycle of pharmaceutical use which abused my body and left me in the most depressed, hopeless, and flattened state.

    I finally said enough of the pharma-tinkering with my body and the MS and tried baking herbal cannabinoids into brownies. In doing so, my alternative treatment made me a criminal. I began to eat a small cube of cannabis brownie three times a day. Within the first month my insomnia disappeared, my bladder issues calmed, nerve tingles of the arms, legs, and feet stilled. I was no longer breaking out in upper body tremors after being out in the world of loud noises, traffic, and the everyday racing of life.  The MS was quieter. I found I wasn’t contemplating suicide and I felt hopeful about my life again – but realized I had become a chronic criminal.

    Cannabinoids are clearly medicinal to our bodies. But there is a strange distinction between which cannabinoids are effective and which ones are legal.  In the case of my MS, appetite stimulation has not been a problem – which is what the Marinol is usually prescribed for. Marinol simply did not work for me. There are other pharmaceutical cannabinoids – such as Nabilone and Sativex – available in other countries, but they remain expensive and less effective than herbal cannabinoids.  Nature created cannabis and the mammalian ECS, not you or me – and it was through the use of herbal cannabinoids that I was able to wean myself from a life of pharma-cocktails and move toward a healthier life. – Just as nature designed.

    This is the first chapter of book in progress titled The Cannabis Papers being published by Illinois NORML.

    More chapters are available for review here.

    *Publius is Bryan Brickner, Julie Falco, Dianna Lynn Meyer, Stephen Young, William Abens, Danielle Schumacher, Derek Rea (1954-2008), David Nott, Dan Linn, Dan S. Wang, Brian Allemana, and many others.

  • by Allen St. Pierre, NORML Executive Director August 4, 2009

    This informative article from CBS News about the government’s claim that there is no need for medical patients to access cannabis, when there is a ‘fake’ cannabis pill on the market, features remarks from NORML advisory board member, professor and author

    Mitch Earleywine, and former deputy drug czar under Bush 1.0 Herb Kleber, which strongly underlines the differences between credible and not credible on the topic of cannabis.

    Credible:

    [One] problem with Marinol is that it’s orally administered,” Dr. Mitch Earleywine, an associate professor of Clinical Psychology at the State University of New York at Albany, said in an email. “Therefore, it takes longer to work than cannabis inhaled from a vaporizer. (Usually 90 minutes at best rather than 15 seconds – a meaningful amount of time to the nauseated.)”

    “It’s harder to control dosage, too, so folks end up discombobulated or without symptom relief,” he added. “In addition, folks who are vomiting can’t hold down the pills.” Earleywine also said that a dose Marinol costs three to five times as much as a comparable dose of medical marijuana.

    Not Credible:

    “Are there actions in the whole plant that you don’t get from just the Marinol? I would be surprised if there wasn’t,” he continued. “The problem is that most of the data about the potential medical actions of the smoked form are anecdotal.”

    Dr. Kleber, who said he has prescribed Marinol to a patient and found it to be effective, points to what he characterizes as a significant advantage of the pill over traditional marijuana: “People don’t abuse it.”

    “Marijuana addiction is becoming common and as a result I’m seeing an increasing number of people who have trouble stopping marijuana,” he said. “Contrary to popular beliefs that there is no marijuana withdrawal, there is marijuana withdrawal. It’s very clear cut.”

    Talk about anecdotal! Dr. Kleber would have readers believe, that cannabis today, as compared to the prior 2,000 years of documented cannabis use by humans is that “Marijuana addiction is becoming common”.

    Really?

    “I’m seeing an increasing number of people who have trouble stopping marijuana”

    Of course you are Herb because as it has been well documented by NORML that the criminal justice system throughout most of the United States presents minor cannabis offenders with the Hobson’s Choice of either going to jail or to visit the offices of the ‘Dr. Klebers’ in America for ‘treatment’.

    Dr. Kleber well knows this, so his statement is for me the working definition of disingenuous!

    Lastly, there is nothing new about Marinol as it has been legal and available for medical patients since the mid 1980s. If the pill worked as Dr. Kleber claims, voters and legislators in the 13 states with medical cannabis laws would not have opted for a whole plant solution.

    Marinol was supposed to be the government’s great ‘silver bullet’ back in the mid 1980s to end the public debate about patients’ need for whole-smoked cannabis–an analog of one of the plant’s major ingredients isolated in pill form.

    Want to know more about ‘pot’ pills vs. the real thing? Checkout NORML’s published paper ‘Marinol vs. Natural Cannabis‘.

    Does the Pot Pill Work?
    The Government Says a Pill Called Marinol Offers the Same Benefits as
    Medical Marijuana. Is it True?

    By Brian Montopoli
    August 4, 2009

    (CBS) “Medical marijuana,” the U.S. Drug Enforcement Administration says, “already exists.”

    They don’t just mean in California. A pill known as Marinol has been legal and approved by the Food and Drug Administration for use with a prescription anywhere in America since 1985.

    It’s active ingredient? Dronabinol, better known as THC, the primary psychoactive element of the cannabis plant.

    “Marinol provides standardized THC concentrations, does not contain the other 400 uncharacterized substances found in smoked marijuana, such as carcinogens or fungal spores, and is not associated with the quick high of smoked marijuana,” said Neil Hirsch, a spokesman for Marinol manufacturer Solvay Pharmaceuticals.

    But Marinol is not the same thing as traditional, smokable marijuana. It is a less complex substance lacking both some of the good components found in traditional marijuana (such as cannabidiol, which has been found to have anti-seizure effects) and the bad or not-yet-fully-understood components (among them potential carcinogens) that can also come with the drug.

    Ken Trainer, a 60-year-old Massachusetts resident who has battled Multiple Sclerosis for 25 years, said he has long been smoking marijuana to deal with the regular tremors he gets in his arms and legs.

    “If I smoke a joint, the tremors go away most times before the joint is gone,” he said. “It makes my life a little easier.” Marinol, by contrast, “didn’t really do much of anything for me,” he said.

    56-year-old Des Moines resident Jeff Elton, who was diagnosed with gastroparesis six years ago, had a similar experience when he was prescribed Marinol to deal with his chronic nausea and vomiting.

    “I felt no relief, I didn’t feel ill, I felt nothing,” he said. “It might as well be M&M’s.”

    Elton said he switched to marijuana, which he smokes through a vaporizer – a device that heats the active ingredients into a vapor instead of burning them. He said it allows him to keep down his food and regain some of the weight he lost while on Marinol. (more…)

  • by Allen St. Pierre, NORML Executive Director December 24, 2008

    By Dale Gieringer, Ph.D, Director, California NORML

    California NORML has recently heard increasing reports that Marinol patients are being drug tested and denied employment for use of marijuana. In particular, we have heard from legal Prop. 215 patients who were denied jobs despite presenting Marinol prescriptions after being re-tested specifically for marijuana. Until recently, Marinol and marijuana were indistinguishable on the standard drug tests, so that patients with a Marinol prescription had a valid medical excuse under federal law for testing positive for marijuana.

    However, special testing techniques have been developed that make it possible to distinguish the two by testing for non-standard cannabinoids that appear in marijuana but not Marinol. Until recently, these tests were expensive and rarely used except in high-profile criminal cases. However, it appears that they are now being routinely used by certain laboratories in cases where Marinol use is claimed. In particular, we have heard reports of such testing being used to disqualify Marinol-using Prop 215 patients by the transportation industry and by Walmart.

    California NORML has accordingly altered its drug testing information to warn against relying on Marinol RXs as a screen for marijuana use: http://www.canorml.org/healthfacts/testing.tips.html

    There is of course no valid scientific or health justification for allowing patients to use Marinol but not marijuana. The only purpose is to enforce compliance with the law. It is a tribute to the power and influence of the drug testing industry that they have prevailed in foisting the costs of this unnecessary and obnoxious procedure on employers.

    California NORML, 2215-R Market St. #278, San Francisco CA 94114

    (415) 563-5858 / www.canorml.org

  • by Paul Armentano, NORML Deputy Director September 9, 2008

    Just days after the New York Times, Scientific American, and other MSM outlets finally got wind that cannabis’ germ-fighting properties can halt the spread of MRSA and other multi-drug resistant pathogens, along comes a second just-released study identifying several new non-cannabinoid compounds in the plant which possess anti-bacterial properties.

    Investigators at the University of Mississippi report the discovery of eleven new non-cannabinoid constituents in cannabis, several of which possess “anti-microbial” (think MRSA), “anti-malarial,” and “anti-leishmanial” (a common skin parasite) activity. Scientists also reported that several of the compounds also possessed anti-inflammatory properties and acted as potent anti-oxidants.

    (The US government, Depart of Health and Human Services actually holds a patent on the use of certain cannabinoids as anti-oxidants and neuroprotectants, which you can read here.)

    In other words, when we speak about the healing powers of the cannabis plant, we really mean the entire cannabis plant. We’re not talking about isolating particular cannabinoids, and we’re most certainly not suggesting patients be forced to consume an oral synthetic version of a single compound a la Marinol.

    Therapeutic cannabis means just that — the therapeutic prowess of the whole plant. We should not advocate for, or accept, anything less.

Page 1 of 212